People who don't trust scientists.
Nations that don't trust each other.
And a lab in a suitcase.
These are some of the ways the world has changed – for worse and for better – in the wake of the pandemic.
This week marks the fifth anniversary of the World Health Organization declaring COVID-19 a pandemic. As the SARS-CoV-2 virus quickly spread around the globe, weaknesses in the world's ability to respond to an infectious disease outbreak became apparent – from an inability to get critical medical supplies to those in need to limits on tracking the disease.
In 2025, how prepared are we if and when the next pandemic strikes?
What's better
The power of a suitcase lab: For years, something has irked Erik Karlsson. He hates that scientists don't have a better handle on what diseases are circulating in a population, whether it's a new virus or one that regularly makes the rounds.
Getting that type of data is "expensive. It's difficult. And it takes a long time," says Karlsson, who is the head of the Virology Unit at Institut Pasteur in Cambodia. "We're finding things maybe a week or two weeks or even a month later."
Meanwhile, the virus is evolving and moving to new locations. "A lot of times we're on the back foot," he says.
COVID highlighted this problem. The medical community couldn't keep up with the virus – for example, an analysis in the journal Science from 2021 found SARS-CoV-2 was circulating as much as two months before the first case was identified in Wuhan, China.
So Karlsson's team has spent the past few years building and testing a method to rapidly track what diseases are around. They created a lab-in-a-suitcase. The idea of a mobile lab or portable science station is not new, but Karlsson's team has worked so their version can get highly specific virus information really quickly.
"We're now ahead of the game," Karlsson says. "We're now detecting things almost in real time."
His lab looks like a typical carry-on — "on wheels with a handle." Open it up and you'll see: "We have a laptop, we have a sequencer [to decode the genome], we have a rice cooker that we use to make gels," Karlsson explains. "We can actually unpack it and have it ready to test in about five minutes."
His team – lead by his postdoctoral researcher Anna Fomsgaard – has used this mobile laboratory system to test for diseases among poultry raised in backyards, and they plan to take it to wet markets where live animals are sold for food (and disease can spill over from animals to people) and in rural hospitals (where obscure new viruses might be present).
The suitcase's superpower is, first, that a swab placed into a little test tube can simultaneously test for multiple diseases.
"My primer can pick up dengue, plus chikungunya, plus Zika, plus Japanese encephalitis," he says – and several other diseases.
What's more, this lab can give the genetic code of the virus while still in the field. Is this human flu or avian flu — or something entirely new? "Within 20 minutes, we're already understanding what viruses are in that sample," he says.
Each lab-in-a-suitcase costs about $40,000, which is a lot cheaper than setting up a brick-and-mortar lab, where a single PCR diagnostic machine can sometimes cost $30,000.
Checking wastewater and more: These kinds of advances in disease surveillance are happening all over the world.
Dr. Paul Friedrichs, who ran the White House Office of Pandemic Preparedness and Response Policy under President Biden and was a chief medical adviser for the military during COVID, says this progress is evident in the U.S. He points to the U.S. Centers for Disease Control and Prevention, which is now using wastewater samples to see what diseases are circulating and automatically collecting data from electronic health records and emergency rooms.
"If you look at where they were in 2019, and where they are today, they've made huge improvements in their ability to see what's happening here in the United States," he says.
Fredriches worries that recent cuts to foreign assistance are hurting disease detection efforts but still counts the progress made as one of the major successes since the early days of COVID.
Linking up: Scientists from Karlsson in Cambodia to Akan Otu in London and Nigeria say the pandemic helped forge connections across continents and scientific fields.
For example, Otu — who studies plant and animal health and is a senior lecturer at the University of Calabar, Nigeria — says that within the scientific community there's a new "distinct appreciation" for the need for collaboration across borders. He says folks working in agriculture and veterinary fields are much more integrated with those focused on human health than just five years ago.
"I think COVID has helped us to understand that we should not work in silos," he says.
But, Fredrichs says, the value of all that work and data depends on how receptive the public is when there's a health crisis.
What's worse
Mistrust in science: A Pew Research Center survey found that – during COVID – more than a quarter of Americans were not confident that scientists were working in the public's interest. And, as of October 2024, some 24% of the American adults had "not too much" confidence in scientists or "none at all" – compared to 13% pre-pandemic.
The lack of public trust has Friedrichs worried. He says it's his biggest concern when thinking about the next pandemic because without the public's confidence it's hard to implement public health measures.
"You can build the perfect test, and if you just walk out and say, 'I built the perfect test' and people don't trust you, they're not going to use it, and then it doesn't matter if it was perfect," he says.
Dr. Luciana Borio says she understands what's behind the drop in public trust. Borio served in the first Trump White House for three years as director for medical and biodefense preparedness and is now a senior fellow for global health at the Council on Foreign Relations. She says, during COVID, many people felt as if they couldn't openly express their skepticism about pandemic responses like vaccines and lockdowns.
"We confused facts and values, and sometimes we thought we were arguing over facts, when in fact, we were arguing over values," she says.
For example, she says, supporters of vaccine mandates felt they were 100% right – and opposing voices were absolutely wrong. "Anybody opposing the prevailing views, they were kind of ostracized and not invited to the scientific debate," she says, adding that only increased the distrust of health authorities.
Countries aren't getting along: The pandemic also sowed distrust between countries.
China didn't share relevant data on COVID. Many low- and middle-income countries watched as wealthier nations received vaccines and medications first.
"It was a very desperate situation," remembers Hadley Sultani Matendechero, deputy director general for health in Kenya. "[Vaccines] in our minds were the only antidote to this catastrophe, but we were not able to access them."
One major effort to fix the lack of trust that emerged from the COVID pandemic has been the Pandemic Treaty, an international agreement between over 190 countries on how to collaborate and share resources.
But, for several years, negotiations have faltered with a major challenge being whether high-income countries will share diagnostics, medications and vaccines in exchange for disease information from low- and middle-income countries when there's a health emergency.
And then in January of this year there seemed to be a new setback. President Trump pulled out of the talks altogether as part of his executive order starting the process of withdrawing the U.S. from the World Health Organization because of its "mishandling of the COVID-19 pandemic … and its inability to demonstrate independence from the inappropriate political influence."
Many observers thought this move would essentially be a death knell for the Pandemic Treaty, "blowing it up," says Lawrence Gostin, a professor of global health law at Georgetown Law and director of the World Health Organization's Center on Global Health Law.
But it didn't.
"In a perverse way, President Trump's withdrawal from the negotiations has energized much of the rest of the world to get this done," he says.
As the U.S. sits on the sidelines, Gostin worries, "as an American, I feel naked, unprotected."
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